Advanced control strategies for the multicolumn countercurrent solvent gradient purification process
Maria M. Papathanasiou
Dept. of Chemical Engineering, Centre for Process Systems Engineering (CPSE), Imperial College London, SW7 2AZ Lodnon, U.K
Artie McFerrin Dept. of Chemical Engineering, Texas A&M University, College Station, TX 77843
Search for more papers by this authorStyliani Avraamidou
Dept. of Chemical Engineering, Centre for Process Systems Engineering (CPSE), Imperial College London, SW7 2AZ Lodnon, U.K
Artie McFerrin Dept. of Chemical Engineering, Texas A&M University, College Station, TX 77843
Search for more papers by this authorRichard Oberdieck
Dept. of Chemical Engineering, Centre for Process Systems Engineering (CPSE), Imperial College London, SW7 2AZ Lodnon, U.K
Artie McFerrin Dept. of Chemical Engineering, Texas A&M University, College Station, TX 77843
Search for more papers by this authorAthanasios Mantalaris
Dept. of Chemical Engineering, Centre for Process Systems Engineering (CPSE), Imperial College London, SW7 2AZ Lodnon, U.K
Search for more papers by this authorFabian Steinebach
Institute for Chemical and Bioengineering, ETH Zurich, Wolfgang-Pauli-Str. 10/HCI F 129, CH-8093 Zurich, Switzerland
Search for more papers by this authorMassimo Morbidelli
Institute for Chemical and Bioengineering, ETH Zurich, Wolfgang-Pauli-Str. 10/HCI F 129, CH-8093 Zurich, Switzerland
Search for more papers by this authorThomas Mueller-Spaeth
Dept. of Chemistry and Applied Biosciences, ChromaCon AG, Technoparkstr. 1, CH-8005 Zurich, Switzerland
Search for more papers by this authorCorresponding Author
Efstratios N. Pistikopoulos
Artie McFerrin Dept. of Chemical Engineering, Texas A&M University, College Station, TX 77843
Corresponding concerning this article should be addressed to E. Pistikopoulos at [email protected].Search for more papers by this authorMaria M. Papathanasiou
Dept. of Chemical Engineering, Centre for Process Systems Engineering (CPSE), Imperial College London, SW7 2AZ Lodnon, U.K
Artie McFerrin Dept. of Chemical Engineering, Texas A&M University, College Station, TX 77843
Search for more papers by this authorStyliani Avraamidou
Dept. of Chemical Engineering, Centre for Process Systems Engineering (CPSE), Imperial College London, SW7 2AZ Lodnon, U.K
Artie McFerrin Dept. of Chemical Engineering, Texas A&M University, College Station, TX 77843
Search for more papers by this authorRichard Oberdieck
Dept. of Chemical Engineering, Centre for Process Systems Engineering (CPSE), Imperial College London, SW7 2AZ Lodnon, U.K
Artie McFerrin Dept. of Chemical Engineering, Texas A&M University, College Station, TX 77843
Search for more papers by this authorAthanasios Mantalaris
Dept. of Chemical Engineering, Centre for Process Systems Engineering (CPSE), Imperial College London, SW7 2AZ Lodnon, U.K
Search for more papers by this authorFabian Steinebach
Institute for Chemical and Bioengineering, ETH Zurich, Wolfgang-Pauli-Str. 10/HCI F 129, CH-8093 Zurich, Switzerland
Search for more papers by this authorMassimo Morbidelli
Institute for Chemical and Bioengineering, ETH Zurich, Wolfgang-Pauli-Str. 10/HCI F 129, CH-8093 Zurich, Switzerland
Search for more papers by this authorThomas Mueller-Spaeth
Dept. of Chemistry and Applied Biosciences, ChromaCon AG, Technoparkstr. 1, CH-8005 Zurich, Switzerland
Search for more papers by this authorCorresponding Author
Efstratios N. Pistikopoulos
Artie McFerrin Dept. of Chemical Engineering, Texas A&M University, College Station, TX 77843
Corresponding concerning this article should be addressed to E. Pistikopoulos at [email protected].Search for more papers by this authorAbstract
The multicolumn countercurrent solvent gradient purification process (MCSGP) is a semicontinuous, chromatographic separation process used in the production of monoclonal antibodies) . The process is characterized by high model complexity and periodicity that challenge the development of control strategies, necessary for feasible and efficient operation and essential toward continuous production. A novel approach for the development of control policies for the MCSGP process, which enables efficient continuous process control is presented. Based on a high fidelity model, the recently presented PAROC framework and software platform that allows seamless design and in-silico validation of advanced controllers for complex systems are followed. The controller presented in this work is successfully tested against disturbances and is shown to efficiently capture the process periodic nature. © 2016 American Institute of Chemical Engineers AIChE J, 62: 2341–2357, 2016
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